Figure 2.

Effects of Cl⁻ channel blockers on endothelium-derived hyperpolarizing factor-induced relaxation in rat mesenteric arterial rings. Arteries were treated with 100 μmol/L L-NAME and 3 μmol/L indomethacin for 30 min, followed by contraction by 1 μmol/L phenylephrine and then relaxation by acetylcholine (ACh). Experiments were performed in the absence (control) and presence of 50 μmol/L NPPB and 100 μmol/L DIDS, and 50 nmol/L apamin plus 50 nmol/L charybdotoxin. Data were expressed as means±SEM (n=6). ^bP<0.05 compared with control group.