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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Anesth Analg. 2014 Apr;118(4):809–817. doi: 10.1213/ANE.0000000000000028

Table 5.

Published trials randomizing patients to BIS-guided anesthesia or usual care or another comparator for reduction of postoperative delirium

Study Patient population Group 1 (n) Group 2 (n) Odds ratio for delirium (group 1 vs group 2)
Sieber et al.(7), 2010 ≥65yo, hip fracture repair under spinal anesthesia with propofol sedation BIS ≥ 80 (57) BIS ≈ 50 (57) 0.35 (0.15-0.82)
Chan et al.(6), 2013 >60yo, elective major noncardiac surgery BIS-guided (450) Routine care (452) 0.58 (0.41-0.80)
Radtke et al.(8), 2013 >60yo, elective major noncardiac surgery BIS-guided (575) Routine care (580) 0.73 (0.54-0.98)
Whitlock et al. (present article) Elective cardiac and thoracic surgery BIS-guided (149) ETAC-guided (161) 0.60 (0.35-1.02)
Meta-analysis of the above studies (1231) (1250) 0.56 (0.42-0.73)