Algorithm for utilizing microsatellite instability alongside clinical pathological factors in stage II and III colorectal cancer. First published in Nat Rev Clinic Oncol 2011;8:222–232, doi:10.1038/nrclinonc.2011.15. Reproduced with permission of Nature Publishing Group, a division of Macmillan Publishers Limited.
Abbreviations: ASCO, American Society of Clinical Oncology; MSI-H, microsatellite instability high; MSI-L, microsatellite instability low; MSS, microsatellite stable.