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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Mod Pathol. 2014 Jan 24;27(9):1255–1266. doi: 10.1038/modpathol.2013.246

Figure 2.

Figure 2

Representative image for expression of VASA (green) and AP2γ (red) in tubules from adult patients with testicular germ cell cancer. A) Tubule with apparently normal spermatogenesis: VASA is expressed in the germ cells with no expression of the intratubular germ cell neoplasia/gonocyte protein AP2γ. B) Tubule with abnormal spermatogenesis: VASA expression is seen in the presumptive spermatocytes towards the lumen (white arrowhead), however germ cells along the basement membrane express VASA (yellow arrowhead) or AP2γ (yellow arrow). A small proportion of cells co-express VASA and AP2γ (white arrow). C) Intratubular germ cell neoplasia tubule: The majority of cells express the intratubular germ cell neoplasia protein AP2γ (yellow arrow) with a small number of cells adjacent to the basement membrane expressing VASA (presumptive spermatogonia; pink arrow). A small number of germ cells expressing VASA are located towards the lumen (presumptive spermatocytes; white arrowhead).