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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Mod Pathol. 2014 Jan 24;27(9):1255–1266. doi: 10.1038/modpathol.2013.246

Figure 3.

Figure 3

Expression of OCT4 (red) and PLAP (green) in intratubular germ cell neoplasia containing tubules from men with testicular germ cell cancer (A,C) and in normal human fetal testis tissue (B). The majority of intratubular germ cell neoplasia cells co-express OCT4 and PLAP (A,C; yellow arrowheads). Occasional OCT4 positive intratubular germ cell neoplasia cells are negative for PLAP expression (A; white arrow). Similar sub-populations of OCT4+/PLAP− (B, white arrow) and OCT4+/PLAP+ (B, yellow arrowheads) cells are also identified in the human fetal testis. In tubules with intratubular germ cell neoplasia, occasional OCT4−/PLAP+ cells are identified (C; yellow arrows), however no similar population is seen in the human fetal testis. Counterstain (DAPI; blue).