Figure 6. Epithelial Scap deletion in the perinatal lung suppresses Wnt/β-catenin signaling.

(A) A schematic representation of mRNAs changed in the canonical Wnt/β-catenin pathway in Scap^Δ/Δ perinatal lung (E17.5) is shown. Green nodes indicate mRNAs that were decreased in Scap^Δ/Δ lungs with respect to control lungs. Wnt pathway genes that were not changed in response to Scap deletion are depicted as empty nodes. (B) Heatmap demonstrates decreased expression of genes encoding a number of key components in the Wnt/β-catenin pathway in Scap^Δ/Δ vs. control mice, n = 3/group.