Table 4. Potential upstream regulators of SCAP/SREBP pathway (ranked by Z-score).

InsigΔ/Δ			ScapΔ/Δ
Gene	State	Z-score	Gene	State	Z-score
IRF7	Activated	4.326	MYC	Activated	5.109
NFkB (complex)	Activated	4.1	MYCN	Activated	4.464
SREBF1	Activated	3.999	PPARGC1A	Activated	3.683
CDKN2A	Activated	3.805	SMAD7	Activated	3.407
STAT1	Activated	3.457	NRF1	Activated	3.283
SREBF2	Activated	3.375	SPDEF	Activated	3.099
IRF1	Activated	3.372	HIC1	Activated	2.985
SPDEF	Activated	3.046	HNF4A	Activated	2.937
AHR	Activated	3.022	ESRRA	Activated	2.852
CEBPA	Activated	2.972	CEBPA	Activated	2.244
TRIM24	Inhibited	−3.065	SREBF1	Inhibited	−5.146
NCOA3	Inhibited	−2.932	SREBF2	Inhibited	−4.227
HOXA10	Inhibited	−2.797	PPARGC1B	Inhibited	−3.614
FOXM1	Inhibited	−2.705	NRIP1	Inhibited	−3.187
E2f	Inhibited	−2.508	NFYA	Inhibited	−3.172
BCL6	Inhibited	−2.497	E2f	Inhibited	−2.795
TCF4	Inhibited	−2.312	Creb	Inhibited	−2.643
NRIP1	Inhibited	−2.262	ESR1	Inhibited	−2.621
MYC	Inhibited	−2.258	Nr1h	Inhibited	−2.59
MEF2D	Inhibited	−2.246	GATA3	Inhibited	−2.388