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. 2014 May 7;9(5):e96026. doi: 10.1371/journal.pone.0096026

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© 2014 Birdno et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Rasters of multiple model neurons in response to stimulation at 200 Figure 7 , but the timeline is expanded to show the responses of model neurons during simulation. a. Simulations were conducted with all of the neuromodulator-dependent mechanisms intact, and subsequently with each of the mechanisms removed individually from each simulation: b. neuromodulator-dependent activation of the pertussis toxin sensitive potassium current (I_KG); c. Neuromodulator-dependent inhibition of a non-pertussis toxin sensitive leak potassium current (I_KL); and d. Neuromodulator-dependent shifting of the activation curve of the hyperpolarization-activated cation current (I_h). The shaded region indicates the time when stimulation was on.