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. 2014 May 7;9(5):e96239. doi: 10.1371/journal.pone.0096239

Figure 5. Caspase 3 and Bim are critical targets of miR-582-5p and miR-363.

Figure 5

0822 cell numbers Bim siRNA and anti-miR-363 rescue experiment with si- and anti-miRNA scrambled controls (A). Bim immunoblot for similar conditions (B). Caspase 3 immunoblot with siRNA treatment (B) as well as 0822 cell numbers for Caspase 3 siRNA and anti-miR-582-5p rescue experiment with si- and anti-miRNA scrambled controls (C). GBM stem cell numbers following transient transfection with anti-miR-582-5p (grey columns) compared to anti-miRNA scrambled controls, with ZVAD caspase inhibitor treatment rescue (D). One-way ANOVA with Bonferroni’s post-test to compare all columns was used to generate p-values. p-values are represented as *, p<.05, **, p<.01, ***, p<.001 Experiments are representative of three or more separate experiments per panel with up to six separate wells per group.