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. 2014 May 7;9(5):e97028. doi: 10.1371/journal.pone.0097028

Figure 6. mdb1 Δ causes resistance to the microtubule-depolymerizing drug TBZ.

Figure 6

(A) mdb1Δ, but not htaAQ and crb2Δ mutants, was strongly resistant to TBZ. Cells were spotted on YES-based plates. Strains used were LD327, LD1067, LD574, and LD197. (B) The phospho-binding residues of Mdb1 are required for reversing the TBZ-resistant phenotype of mdb1Δ. Cells were pregrown in a thiamine-free medium for 20 h before being spotted on TBZ-containing thiamine-free plates. Strains used were LD327, DY15630, DY15603, DY15604, and DY15605.