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. 2014 May 7;9(5):e96055. doi: 10.1371/journal.pone.0096055

Figure 11. Extracellular matrix remodeling in chronic anthracycline cardiotoxicity and post-treatment follow up.

Figure 11

Gene expression of collagen I (A, F), collagen III (B, G), collagen IV (C, H) and collagen VI (D, I) in the left and right ventricular myocardium, respectively. Biochemical analysis of collagenous proteins estimated by hydroxyproline determination in the left (E) and right (J) ventricular myocardium. Statistical significances (One Way ANOVA/One Way ANOVA on Ranks according to data character, P<0.05) within each study period (*). Detection of collagen fibers (particularly of collagen type I) using Picrosirius red staining in the left (K) and right (L) ventricular myocardium. Scale bar - 20 µm. C - control group, DAU - daunorubicin group, FU - follow up.