Figure 10. Tentative model for the role of Map9 in zebrafish development. Map9 is required for MT dynamics. MTs are key components of the mitotic spindle (mitosis) and cilia. MTs and mitosis are essential for the formation of the YSL and epiboly. YSL is required for endoderm development and nodal signaling and the cilia of the KV are responsible for propagating nodal signals involved in left/right asymmetry. As indicated on the schematic, most of these pathways are interdependent. Black arrows indicate the possible role of Map9 during zebrafish development suggested by this and previous studies,^9-11,19 and gray arrows summarize literature data.