| GO term |
Total No. genes in set |
No. genes regulated |
P value |
| cell cycle |
828 |
225 |
2.55E-12 |
| cell cycle process |
647 |
185 |
5.77E-12 |
| cell cycle phase |
548 |
158 |
2.52E-10 |
| mitotic cell cycle |
470 |
139 |
5.97E-10 |
| DNA metabolic process |
594 |
157 |
1.58E-07 |
| regulation of cell cycle |
526 |
139 |
2.00E-06 |
| M phase |
344 |
97 |
1.95E-05 |
| chromosome |
471 |
124 |
1.72E-05 |
| interphase of mitotic cell cycle |
257 |
76 |
7.92E-05 |
| M phase of mitotic cell cycle |
246 |
73 |
1.19E-04 |
| interphase |
261 |
76 |
1.37E-04 |
| G1/S transition of mitotic cell cycle |
126 |
45 |
1.21E-04 |
| mitosis |
239 |
71 |
1.44E-04 |
| chromosome, centromeric region |
124 |
44 |
1.72E-04 |
| chromosome segregation |
98 |
37 |
2.82E-04 |
| cell division |
295 |
82 |
3.30E-04 |
| condensed chromosome, centromeric region |
69 |
29 |
3.80E-04 |
| chromosome organization |
518 |
125 |
0.001 |
| mitotic prometaphase |
73 |
29 |
0.001 |
| regulation of cell cycle process |
292 |
78 |
0.003 |
| condensed chromosome |
124 |
41 |
0.003 |
| condensed chromosome kinetochore |
64 |
25 |
0.008 |
| DNA replication |
147 |
45 |
0.008 |
| response to DNA damage stimulus |
427 |
103 |
0.009 |
| DNA conformation change |
159 |
47 |
0.013 |
| chromatin |
206 |
56 |
0.028 |
| negative regulation of cell cycle |
194 |
53 |
0.037 |
| cell cycle checkpoint |
180 |
50 |
0.037 |
| DNA repair |
287 |
72 |
0.041 |
| kinetochore |
75 |
26 |
0.047 |
| chromatin remodeling |
67 |
24 |
0.049 |
| Gene ontology classes enriched in SMC2-knockdown MYCN-expressing SH-EP cells |
| GO term |
Total No. genes in set |
No. genes regulated |
P value |
| gene expression |
1680 |
581 |
3.86E-15 |
| response to DNA damage stimulus |
427 |
179 |
1.29E-10 |
| DNA metabolic process |
594 |
223 |
1.36E-10 |
| cell cycle process |
647 |
244 |
4.60E-09 |
| mitotic cell cycle |
470 |
188 |
4.64E-09 |
| cell cycle |
828 |
299 |
5.90E-09 |
| chromatin modification |
328 |
139 |
2.72E-08 |
| DNA repair |
287 |
124 |
7.03E-08 |
| covalent chromatin modification |
194 |
90 |
3.67E-07 |
| histone modification |
192 |
89 |
4.78E-07 |
| cell cycle phase |
548 |
204 |
8.24E-07 |
| regulation of gene expression |
2625 |
796 |
1.02E-06 |
| chromosome organization |
518 |
194 |
1.18E-06 |
| chromatin organization |
396 |
154 |
3.28E-06 |
| transcription factor binding |
284 |
116 |
1.18E-05 |
| regulation of cell cycle |
526 |
191 |
2.23E-05 |
| cell division |
295 |
118 |
3.28E-05 |
| mitosis |
239 |
98 |
1.05E-04 |
| chromosome |
471 |
171 |
1.05E-04 |
| M phase of mitotic cell cycle |
246 |
100 |
1.25E-04 |
| chromosome, centromeric region |
124 |
58 |
2.26E-04 |
| regulation of transcription, DNA-dependent |
2324 |
692 |
3.00E-04 |
| transcription cofactor activity |
345 |
130 |
3.10E-04 |
| protein binding transcription factor activity |
352 |
132 |
3.42E-04 |
| transcription factor binding transcription factor activity |
349 |
131 |
3.52E-04 |
| condensed chromosome, centromeric region |
69 |
37 |
4.79E-04 |
| interphase of mitotic cell cycle |
257 |
101 |
6.15E-04 |
| interphase |
261 |
102 |
7.27E-04 |
| M phase |
344 |
127 |
0.001 |
| regulation of gene expression, epigenetic |
96 |
46 |
0.001 |
| chromatin remodeling |
67 |
35 |
0.002 |
| chromosomal part |
389 |
140 |
0.002 |
| negative regulation of gene expression |
580 |
197 |
0.002 |
| mitotic prometaphase |
73 |
37 |
0.002 |
| DNA-dependent transcription, initiation |
76 |
38 |
0.002 |
| positive regulation of transcription, DNA-dependent |
664 |
220 |
0.003 |
| condensed chromosome kinetochore |
64 |
33 |
0.004 |
| cell cycle checkpoint |
180 |
72 |
0.008 |
| posttranscriptional regulation of gene expression |
243 |
92 |
0.008 |
| transcription, DNA-dependent |
794 |
254 |
0.01 |
| condensed chromosome |
124 |
53 |
0.011 |
| regulation of transcription from RNA polymerase II promoter |
792 |
253 |
0.011 |
| positive regulation of gene expression |
712 |
230 |
0.011 |
| chromosome segregation |
98 |
44 |
0.012 |
| transcription initiation from RNA polymerase II promoter |
51 |
27 |
0.012 |
| regulation of cell cycle process |
292 |
106 |
0.013 |
| transcription coactivator activity |
197 |
76 |
0.016 |
| regulation of cell cycle arrest |
188 |
73 |
0.017 |
| spindle |
160 |
64 |
0.018 |
| DNA recombination |
130 |
54 |
0.02 |
| kinetochore |
75 |
35 |
0.025 |
| microtubule organizing center |
326 |
114 |
0.035 |
| negative regulation of transcription, DNA-dependent |
521 |
171 |
0.039 |
| protein serine/threonine kinase activity |
364 |
125 |
0.039 |
| DNA damage response, signal transduction by p53 class mediator |
71 |
33 |
0.04 |
| G2/M transition of mitotic cell cycle |
101 |
43 |
0.049 |
