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Schematic model depicting the key role of CIC in hepatic lipogenesis. CIC, citrate carrier; CL, ATP-citrate lyase; CS, citrate synthase; IDH, isocitrate dehydrogenase; MDH, malate dehydrogenase; ME, malic enzyme; NADH, reduced nicotinamide adenine dinucleotide hydrate; NAD+, oxidized nicotinamide adenine dinucleotide; OGC, oxoglutarate carrier; PC, pyruvate carboxylase; Pi, inorganic phosphate; PYC, pyruvate carrier.
