Table 1. Genetic stability of the PB2-RSVF virus.
Percentage of plaques positive for RSV F protein* | |||||
---|---|---|---|---|---|
Passage 1 | Passage 2 | Passage 3 | Passage 4 | Passage 5 | |
Exp. 1 | 100% | 100% | 90% | 100% | 90% |
Exp. 2 | 100% | 100% | 100% | 90% | 80% |
Exp. 3 | 100% | 90% | 90% | 100% | 90% |
The respective viral supernatants were subjected to standard virus plaque assays in confluent AX4/PB2 cells. Ten plaques were marked per well, which were then subjected to an immunodetection assay with an anti-RSV F protein antibody. The percentage of viral plaques that were positive for the RSV F protein among the 10 plaques is presented. The results of three independent experiments (Exp.) are shown.