Table 3. Virus titers in the lungs of mice challenged with RSVa.
| Immunogen (PFU) | Virus Titer (mean log10 PFU ± SD/g) |
|
|---|---|---|
| PB2-RSVF virus | 104 | 5.4 ± 0.07 |
| 105 | 5.6 ± 0.2 | |
| 106 | 5.4 ± 0.2 | |
| HI-RSV | 106 | 5.3 ± 0.02 |
| PBS | 5.4 ± 0.08 | |
a
Mice immunized with the indicated agents (104, 105, or 106 PFU of the PB2-RSVF virus or controls [heat-inactivated RSV (HI-RSV) and PBS) were challenged with 106.5 TCID50 of RSV two weeks after the boost immunization. Three mice per group were euthanized on day 4 post-challenge for virus titration in the lungs.