a: NECA-induced vascular responses in aortic rings of A2AAR+/+ and A2AAR−/− mice fed NS and HS diet. Values are means ± SE. *p<0.05 between HS-A2AAR+/+ vs. NS-A2AAR+/+, $p<0.05 between HS-A2AAR+/+ vs. HS-A2AAR−/− , and #p<0.05 between NS-A2AAR+/+ vs. NS-A2AAR−/−, n = 6. On the y-axis, postive and negative values represent relaxation and contraction, respectively. b: Effects of SCH 58261 (10−6 M) on NECA-induced vascular responses in aortic rings isolated from HS and NS fed mice. Values are means ± SE. *p<0.05 between HS-A2AAR+/+ vs. NS-A2AAR+/+, $p<0.05 between HS-A2AAR+/+ vs. HS-A2AAR+/+ with SCH 58261, and #p<0.05 between NS-A2AAR+/+ vs. NS-A2AAR+/+ with SCH 58261, n = 6.