a: Effects of DPCPX (10−5 M) on NECA-induced vascular response in NS and HS fed A2AAR+/+ aortic rings. Values are mean ± SE. #p<0.05 between NS-A2AAR+/+ vs. NS-A2AAR+/+ with DPCPX, and *p<0.05 between HS-A2AAR+/+ vs. NS-A2AAR+/+, n = 4-6. b: Effects of DPCPX (10−5 M) on NECA-induced vascular response in NS and HS fed A2AAR−/− aortic rings. Values are mean ± SE. #p<0.05 between NS-A2AAR−/− vs. NS-A2AAR−/− with DDMS, and $p<0.05 between HS-A2AAR−/− vs. HS-A2AAR−/− with DDMS, n = 4-6. c: CCPA-induced vascular response in aortic rings isolated from A2A AR+/+ and A2A AR−/− mice fed NS and HS containing diet. Values are means ± SE. *p<0.05 between HS-A2AAR+/+ vs. NS-A2AAR+/+, and $p<0.05 between HS-A2AAR+/+ vs. HS-A2A AR−/− , and #p<0.05 between NS-A2AAR+/+ vs. NS-A2AAR−/−, n = 4.