Table 2.

Colorectal cancer

References	Strain/species	Sex	Agea	Tumor model	Resveratrol dose and administration	Effect on tumorigenesisb
Tessitore et al. (2000)	F344 rats	M	8 weeks	AOM	In drinking water; 200 μg/kg BW daily; 10 days before initiation, continued for 100 days	Positive
Schneider et al. (2001)	APCMin/+ mice	M	5 weeks	Spontaneous tumors	0.01% in drinking water; between 0.3 and 0.4 mg/mouse daily for 7 weeks	Positive
Ziegler et al. (2004)	APCMin/+ mice	M	43 days	Spontaneous tumors	In diet; 4, 20, or 90 mg/kg BW daily for 7 weeks	Unchanged
Sale et al. (2005)	APCMin/+ mice	M	4 weeks	Spontaneous tumors	0.05 or 0.2% in diet; 60 or 240 mg/kg BW daily for 10–14 weeks	Positivec
Sengottuvelan & Nalini (2006)	Wistar rats	M	Adult	DMH	I.g.; 8 mg/kg BW; daily; 2 weeks before first DMH – final DMHd	Positive
Sengottuvelan & Nalini (2006)	Wistar rats	M	Adult	DMH	I.g.; 8 mg/kg BW; daily; 2 days after final DMH – 15 weeks after final DMHd	Positive
Sengottuvelan & Nalini (2006)	Wistar rats	M	Adult	DMH	I.g.; 8 mg/kg BW; daily; on day of first DMH – 30 weeks afterd	Positive
Majumdar et al. (2009)	SCID mice	F	7 weeks	HCT-116 (wt) cells	Gavage; 150 mg/kg BW; daily; 15 days after injection for 3 weeks	Positive
Alfaras et al. (2010)	Sprague–Dawley rats	M	8 weeks	DMH	Gavage; 60 mg/kg BW; daily; 7 days before initiation for 49 days	Positive

AOM, azoxymethane; BW, body weight; DMH, 1,2-dimethylhydrazine; i.g., intragastric intubation; M, male; SCID, severe combined immunodeficiency.

^aAge in table indicates age of animal when study was started; either when tumors were initiated or when resveratrol was administered, depending on study design.

^bReview authors' interpretation of paper results with a focus on tumor outcomes.

^cUnchanged for lower dose.

^dDMH was given once weekly for 15 weeks, and then the rats were killed 15 weeks after the last DMH injection (30 weeks after initial DMH exposure).