. 2014 Feb 5;21(3):R209–R225. doi: 10.1530/ERC-13-0171
This work is licensed under a Table 5.
Prostate cancer
| References | Strain/species | Sex | Agea | Tumor model | Resveratrol dose and administration | Effect on tumorigenesisb |
|---|---|---|---|---|---|---|
| Harper et al. (2007) | TRAMP mice | M | 5 weeks | Spontaneous tumors | 0.0625% in diet; daily for 23 weeks | Positive |
| Seeni et al. (2008) | TRAP rats | M | 3 weeks | Spontaneous tumors | 0.005, 0.01, or 0.02% in drinking water; daily for 7 weeks | Positive |
| Seeni et al. (2008) | Nude mice | M | 6 weeks | PLS30 cells | 0.01 or 0.02% daily in drinking water; 1 week after cell injection – 6 weeks after | Unchanged |
| Wang et al. (2008) | Nude mice | M | 5 weeks | LNCaP cells | 0.005 or 0.01% in diet; daily; 2 weeks before cell injection – 7 weeks after | Unchangedc |
| Dias et al. (2013) | Nude mice | M | 6–7 weeks | LNCaP cells | Gavage; 50 mg/kg BW; every other day; 2 weeks prior to cell injection – 5 weeks after | Positive |
BW, body weight; M, male; TRAP, transgenic rats for adenocarcinoma of prostate; TRAMP, transgenic adenocarcinoma of mouse prostate.
a
Age in table indicates age of animal when study was started; either when tumors were initiated or when resveratrol was administered, depending on study design.
b
Review authors' interpretation of paper results with a focus on tumor outcomes.
c
Resveratrol delayed tumor growth at 3 weeks (both doses) and 4 weeks (higher dose only) post injection compared with mice on control diet, but there were no differences in tumor size after 7 weeks at the end of the study.