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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Ann Neurol. 2014 Mar 13;75(4):508–524. doi: 10.1002/ana.24100

Figure 4.

Figure 4

Neurons in the white matter are resistant to cell death. (A) NeuN-positive neurons (green cells) are abundant throughout the neocortex and white matter (WM) at 0.65 gestational age (GA). (B–C) The density of degenerating cells that labeled for activated caspase-3 (AC3) (B) and Hoechst (C) in the white matter were significantly increased at 24 h after HI at 0.65 GA. (D) Representative photomicrograph of degenerating cells in the white matter at 24h after HI that labeled for AC3 (red cells; arrows) and Hoechst (blue condensed nuclei; arrows). Note the presence of many normal-appearing NeuN-positive neurons (green cells; arrowheads), which showed no evidence of injury. Scale bars A = 500 μm, D = 30 μm. *p<0.005.