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Cleaved Notch-1 (ICN1) immunohistochemical staining of human foreign body granulomas and cutaneous sarcoidosis. Prominent nuclear ICN1 staining within mono- and multinucleated histiocytes in FBGR (A, 100× magnification and B, 600× magnification). ICN1 demonstrated cytoplasmic staining within epithelioid histiocytes and MNGCs in cutaneous sarcoidosis (C, 100× magnification and D, 600× magnification). ICN1 expression by epidermal keratinocytes (E, 600× magnification).
