Table 3.

Recent Studies of Scalp Hypothermia

Reference	Year	Randomized	No. in Intervention/Control Group	Cooling Method	Chemo Regimen	Hair Loss Grading	Intervention Group	Control Group
Mols68	2009	No	98/168	Paxman system	AC, FEC, FAC, DAC	No wig required	52%	3%
Auvinen69	2010	No	64/−	Gel-cap	A, D, D+FEC, FEC	Modified CTC,a Grade 1 Grade 2	69% 17%	-
Kargar70	2011	No	31/32	Penguin Cap	D, ABVD, BEP, CHOP	WHO, Grade 3 or 4 Week 2 Week 6	23% 50%	61% 75%
van den Hurk71	2012	No (registry)	1411/−	Various	Various	No wig required	50%	-
van den Hurk72	2012	Nob	53/15	Paxman system	D	No wig required 90 min PICT 45 min PICT	79% 95%	27%
Lemieux112	2012	No	110/26	Penguin Cap or Dignicap	Various	Success per:c Hairstylist Patient	34% 49%	9% 4%
Van den Hurk113	2013	No	160/86	Paxman system	Various	WHO, Grade 2 Grade 3	50% 30%	7% 91%
Betticher74	2013	No	128/71/39d	Paxman system or cold cap	D as weekly or Q 3 weekly ± other chemotherapy	WHO Grade 3 or 4 Paxman D Q 3 week D Q weekly Cold cap D Q 3 week D Q weekly	23% 7% 27% 8%	74% 17%

AC = adriamycin, cyclophosphamide; FEC = 5-fluorouracil, epirubicin, cyclophosphamide; FAC = 5-fluorouracil, adriamycin, cyclophosphamide; DAC= docetaxel, adriamycin, cyclophosphamide; A = adriamycin; D = docetaxel; ABVD = adriamycin, bleomycin, vinblastine, dacarbazine; BEP = bleomycin, etoposide, cisplatin; CHOP = cyclophosphamide, adriamycin and vincristine plus prednisolone; WHO = World Health Organization; CTC = Common Toxicity Criteria; Q = every/

^aModified CTC were used: Grade 0=No hair loss, Grade 1=Thinning of hair, and Grade 2= Patchy or major hair loss or complete alopecia.

^bThe study was an observational study followed by randomization if the initial phase of study suggested significant benefit.

^cSuccess was defined as moderate, little, or no hair loss.

^dStudy compared three groups: Paxman system=128, cold cap=71, and control=39.