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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Dev Biol. 2014 Mar 18;390(1):1–13. doi: 10.1016/j.ydbio.2014.03.004

Figure 6. Neural crest cells undergo apoptosis in Foxi3 mutant arches.

Figure 6

(A) Neural crest cells, stained with AP2α, undergo apoptosis, indicated by active caspase-3 in the distal tip of Foxi3 mutant arches (box 3). Some apoptosis in the proximal region of wild type and Foxi3 mutant arches (boxes 1 and 2). We excluded these cells from neural crest cell death quantification because they exist in both populations and are AP2α-negative. Higher magnification images of the regions highlighted with white boxes are shown below. Scale bars are 100μm. (B) The increase in apoptosis in Foxi3 mutant arches is statistically significant (p=0.04). Foxi3 mutants n=5; wild type n=6 embryos. Error bars represent the standard error of the mean.