Fig 3.

Interactions between gut microbiota and the endocannabinoid system: impact on gut barrier function and metabolic inflammation. Obesity (nutritional or genetic) is associated with changes in the gut microbiota composition and pathophysiological changes, whereby the endocannabinoid system tone is altered. This phenomenon is associated with the development of gut permeability, metabolic endotoxemia, metabolic inflammation, and altered adipose tissue metabolism (adipogenesis). From Delzenne NM, et al.⁵⁶