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. 2011 Sep;30(9):612–619. doi: 10.5732/cjc.011.10225

Figure 1. Survival and progression at the skeletal level of prostate cancer cell types expressing different levels of PDGFRα.

Figure 1.

The PC3-ML sub-line expressed higher levels of the receptor and produced macroscopic skeletal metastases in mice inoculated with cancer cells in the hematogenous circulation via the left cardiac ventricle injection. PC3-N cells expressed lower levels of PDGFRα than did PC3-ML cells and could only survive two weeks in the bone after their dissemination. DU-145 cells were found negative to PDGFRα expression and disappeared from the skeleton between 72 h and one week post inoculation.