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. 2011 Dec;30(12):821–830. doi: 10.5732/cjc.011.10289

Figure 4. DNA hypermethylation contributes in part to the down-regulated expression of miR-124 in MDA-MB-231 cells.

Figure 4.

A, the methylation status of CpG islands around MIR124-1, MIR124-2, and MIR124-3 were analyzed by bisulfite sequencing. Closed circle, methylated CpG site; open circle, unmethylated CpG site. B, compared to control, expression of miR-124 is up-regulated in MDA-MB-231 cells treated with demethylation agent 5-aza-2-deoxycytidine (AZA).