Figure 2. Histological examination of the renal cell carcinoma and corresponding nasal metastasis in a 59-year-old Chinese man. A, the renal cancer comprises solid sheets of pale to clear tumor cells and an arborizing vascularity, supporting the diagnosis of high grade clear cell RCC (scale bar = 25 µm); B, the fragments of nasal mucosa contains cellular tumor islands with sarcomatoid changes, a feature that is indicative of aggressive RCC (scale bar = 25 µm); C, interspersed narrow vessels (scale bar = 100 µm) are present in the tumor, reflecting a complex vascular network; D, the nasal metastasis presents as alveolate patterns of pale to clear cells (scale bar = 200 µm), resembling the renal tumor, supporting the diagnosis of metastatic RCC.