Table 5. Summary of adverse events experienced by at least 10% of 52 patients treated with lapatinib plus capecitabine.

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Total
PPE	25 (48.1)	6 (11.5)	0	0	31 (59.6)
Diarrhea	20 (38.5)	4 (7.7)	0	0	25 (48.1)a
Rash	22 (42.3)	1 (1.9)	2 (3.8)	0	25 (48.1)
Hyperbilirubinemia	4 (7.7)	12 (23.1)	2 (3.8)	0	18 (34.6)
Fatigue	11 (21.2)	4 (7.7)	1 (1.9)	0	16 (30.8)
Nausea	9 (17.3)	1 (1.9)	0	0	10 (19.2)
Neutropenia	0	4 (7.7)	1 (1.9)	2 (3.8)	7 (13.5)

Data are presented as number of patients, with the percentage in parentheses.

^aThe grade of diarrhea for one patient (1.9%) was unknown.

PPE, palmar-plantar erythrodysesthesia.