Table 1. MicroRNA profiling studies in pancreatic adenocarcinoma.

Reference	Study specifications	Up-regulated miRNAs	Down-regulated miRNAs
Lee 2007[11]	RT-PCR assay testing for 222 miRNAs in 28 PDAC tissues and 15 adjacent benign tissues, 4 CP tissues, 6 normal pancreas tissues, and 9 PDAC cell lines	miR-221, miR-424, miR-301, miR-100, miR-376a, miR-125b-1, miR-21, miR-16-1, miR-181a,c, miR-92-1, miR15b, miR-155, let-7f-1, miR-212, miR-107, miR-24-1,2, let-7d	miR-345, miR-142P, miR-139
Zhang 2009[36]	RT-PCR assay testing for 95 miRNAs in 5 PDAC tissues and adjacent benign tissues, 3 PDAC cell lines, 1 CP tissue	miR-196a, miR-190, miR-186, miR-221, miR-222, miR-200b, miR-15b, miR-95	None found
Kent 2009[37]	Microarray testing for 321 miRNAs in 21 PDAC cell lines and 2 non-transformed human pancreatic ductal epithelial cell lines	miR-200a, miR-29b, miR-182, miR-141, miR-222, miR-191, miR-15a, miR-361, miR-17-3p, miR-200b, miR-26b, miR-155, miR-16, miR-96, miR-30a-5p, miR-7, miR-429, miR-30c, miR-30b, miR-345, miR-31, miR-193b, miR-30d, miR-26a, miR-134, miR-151	let-7c, let-7b, miR-99b, miR-204, miR-125a, miR-143, let-7e, miR-34a, miR-145, miR-199a, miR424, miR-199a*
Bloomston 2007[38]	Microarray testing for 326 human miRNAs in 65 PDAC tissues and adjacent benign tissues, 42 CP tissues and adjacent benign tissues	miR-221, miR-181a, miR-155, miR-210, miR-213, miR-181b, miR-222, miR-181b-2, miR-21, miR-181b-1, miR-181c, miR-220, miR-181d, miR-223, miR-100-1/2, miR-125a, miR-143, miR-10a, miR-146, miR-99, miR-100, miR-199a-1,miR-10b, miR-199a-2, miR-10b, miR-199a-2, miR-107, miR-103-2, miR-125b-1, miR-205, miR-23b, miR-23a	miR-148a, miR-148b, miR-375
Szafranska 2007[39]	Microarray testing for 377 miRNAs in 33 PDAC tissues and adjacent benign tissues	miR-205, miR-143, miR-145, miR-146a, miR-196b, miR-93, miR-31, miR-210, miR-196a, miR-18a, miR-203, miR-150, miR-155, miR-221, miR-222, miR-223, miR-224	miR-29c, miR-216, miR-217, miR-375, miR-148a, miR-96, miR-148b, miR-141, miR-130b

Results of studies attempting to determine the miRNA expression signature of pancreatic adenocarcinoma. PDAC, pancreatic ductal adenocarcinoma; CP, chronic pancreatitis.