Table 2. Dysregulated microRNAs, their functions, and possible molecular targets in pancreatic adenocarcinoma.

MicroRNA(s)	Role	Molecular target(s)	Biological functlon(s)	Reference(s)
miR-15a	Tumor suppressor	WNT3A, FGF7	Increase proliferation and growth; Inhibit apoptosis	Zhang 2010[51]
miR-27a	Oncogene	Spry2	Increase growth, migration, and colony formation in vitro	Ma 2010[49]
miR-34a	Tumor suppressor	p53	Inhibit growth and proliferation	Kent 2009[37]
miR-96	Tumor suppressor	K-Ras/Akt	Decrease Invasion, migration, and growth	Yu 2010[52]
miR-132	Oncogene	PRB/E2F	Increase proliferation	Park 2011[48]
miR-155	Oncogene	TP53INP1	Decrease apoptosis	Gironella 2007[41]
miR-194, miR-200b, miR-220c, miR-429	Oncogene	EP300	Increase growth and metastasis	Mees 2010[45]
miR-212	Oncogene	pRB/E2F	Increase proliferation	Park 2011[48]
miR-214	Oncogene	ING4	Reduce sensitivity to GEM-induced apoptosis; increase growth and angiogenesis	Zhang 2010[51]
miR-301a	Oncogene	NK-κB-repressing factor	Increase growth	Lu 2011[50]
miR-375	Tumor suppressor	PDK1/Akt, 14-3-3zeta	Decrease growth; increase apoptosis	Tsukamoto 2010[53]
miR-421, miR-483-3p	Oncogene	DCP4/Smad4	Increase proliferation and colony formation in vitro	Hao 2010[47], Hao 2011[46]