Table 3. MicroRNA profiling studies in hepatocellular carcinoma.

Reference	Study specifications	Up-regulated miRNAs	Down-regulated miRNAs
Murakami 2006[55]	Microarray testing for 180 mature and 206 precursor miRNAs in 24 HCC tissues and 22 adjacent non-tumor tissues, 9 CH samples	pre-miR-18, miR-18, miR-224	miR-125a, miR-195a, miR-199a, miR-199a*, miR-200a
Budhu 2008[56]	Microarray testing for unspecified number of miRNAs in 29 metastatic HCC tissues and 102 non-metastatic HCC tissues	miR-185, miR207, miR-219-1, miR-338	let-7g, miR-1-2, miR-9-2, miR-15a, miR-19a, miR-30a, miR-30c-1,miR-30e, miR-34a, miR-122a, miR-124a-2, miR-125b-2, miR-126, miR-148a, miR-148b, miR-194
Wang 2008[57]	RT-PCR assay testing for 157 miRNAs in 19 HCC tissues and adjacent benign tissues	miR-9, miR-9*, miR-21, miR-25, miR-137, miR-151, miR-155, miR-182, miR-182*, miR-183, miR-186, miR-216, miR-221, miR-222, miR-224, miR-301,	miR-139, miR-145, miR-214
Huang 2007[58]	Microarray testing for 331 miRNAs in 10 HCC tissues and adjacent benign tissues from patients without viral hepatitis	miR-324-5p, miR-374 let-7a, let-7b, let-7c, let-7d, let-7e, let-7g, let-7i, miR-21, miR-22, miR-98, miR-126, miR-126-3p, miR-195, miR-352	miR-235

Results of studies attempting to determine the miRNA expression signature of hepatocellular carcinoma. HCC, hepatocellular carcinoma; CH, chronic hepatitis.