Table 3.
MBL2 genotypes and infections in 72 patients with ASCT during the 6 months of follow-up
| |
AA
|
AO/OO
|
RR (95% CI) |
P-value*
|
|---|---|---|---|---|
| |
Patients (%)
|
Patients (%)
|
|
|
| n = 53 | n = 19 | |||
|
Types of Infection
|
|
|
|
|
| -Pneumonia |
2 (3.8) |
2 (10.5) |
2.8(0.4-18.4) |
0.28 |
| -Sepsis |
22 (41.5) |
9 (47.4) |
1.1 (0.6-2.0) |
0.66 |
| -VCI |
6 (11.3) |
2 (10.5) |
0.9 (0.2-4.2) |
1.00 |
| -UTI |
5 (9.4) |
3 (15.8) |
1.7 (0.4-6.3) |
0.43 |
|
Major infection
|
6 (11.3) |
5 (26.3) |
2.32 (0.80-6.74) |
0.15 |
|
Gram-positive infections
|
14 (26.4) |
9 (47.4) |
1.8 (0.9-3.4) |
0.09 |
| -S. epidermidis |
9 (17) |
7 (36.8) |
2.2 (0.9-5.0) |
0.11 |
| -S. aureus |
1 (1.9) |
0 (0) |
-- |
1.00 |
| -Other |
|
|
|
|
|
Gram-negative infections
|
19 (35.8) |
6 (31.6) |
0.9 (0.4-1.9) |
0.74 |
|
Viral infections
|
1 (1.9) |
1 (5.3) |
2.8 (0.2-42.4) |
0.46 |
| -CMV |
0 (0) |
1 (5.3) |
-- |
0.26 |
|
Fungal infections
|
1 (1.9) |
4 (21.1) |
11.5 (1.3-93.7) |
0.016 |
|
-
Candida |
1(1.9) |
2 (10.5) |
5.6 (0.5-58.1) |
0.17 |
|
-
Aspergillus |
0 (0) |
1 (5.3) |
-- |
0.26 |
| -Mucor |
0 (0) |
1 (5.3) |
-- |
0.26 |
|
Nº deaths
|
4 (7.5) |
3 (15.8) |
2.1 (0.5-8.5) |
0.37 |
|
Cause of death
|
|
|
|
|
| -Infection |
0 |
3 |
-- |
0.05 |
| -Progression |
3 |
0 |
-- |
|
| -Unknown (not infection) | 1 | 0 | -- |
*Two-tailed Chi-squared test or Fisher exact test as corresponding.
RR: risk ratio; CI: confidence interval.
VCI: Venous catheter infection; UTI: Urinary tract infection.
AA genotype: patients homozygous for wild-type structural allele (A).
AO/OO genotype: patients heterozygous or homozygous for the B, C or D alleles.