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In vivo depletion assay with anti-CD4 and anti-CD8 monoclonal antibodies. Mice were challenged with L. amazonensis after vaccination with F1sap (A) and F3sap (B) vaccines and treated with rat serum, anti-CD4+ or anti-CD8+, or the combination of anti-CD4 and anti-CD8 MAbs. Results are shown as the mean ± SD of the footpad measurements of one experiment (four to five animals per treatment) along the time. *p < 0.05, different from the F1sap (A) and F3sap (B) vaccines.
