Table 2. Estimated Risk Factors for Development of Chronic Hepatitis B in Inactive HBV Carrier State a, b, c.
| Risk Factors | HBeAg Negative CHB (n = 15) | Inactive Carrier State (n=338) | P value |
|---|---|---|---|
| Gender | 0.11 | ||
| Male | 12 | 192 | |
| Female | 3 | 148 | |
| Positive family Hx | 10 of 13 (76.9) | 152 of 194 (78.4) | 1.000 |
| Age at study entry, y | 31.3 ± 12.4 | 35.5 ± 11.6 | 0.17 |
| Age at study termination, y | 40.9 ± 13.1 | 44.4 ± 12.0 | 0.27 |
| Detectable serum HBV DNA at study entry | 8 of 15 (53.3) | 203 of 340 (59.7) | 0.71 |
| Mean HBV DNA at study entry, IU/mL | 831.7 ± 991.3 | 687.4 ± 887.6 | 0.818 |
| Serum AST at study entry, IU/L | 23.4 ± 8.5 | 24.5 ± 7.7 | 0.63 |
| Serum ALP at study entry, IU/L | 183.6 ± 181.2 | 170.6 ± 92.4 | 0.65 |
| Serum ALT at study entry, IU/L | 24.4 ± 11.8 | 23.8 ± 9.3 | 0.8 |
| Hx of non-HBV related ALT elevation | 11 of 15 (73.3) | 88 of 384 (22.9) | < 0.001 d |
a Abbreviations: CHB, chronic hepatitis B; HBV, hepatitis B virus; AST, aspartate transaminase; ALT, alanine transaminase; ALP, alkaline phosphatase; Hx, history.
b Data are presented in No. (%) or Mean ± SD.
c Non-HBV related ALT elevation, elevated serum ALT Levels in absence of HBV replication (ie, HBV < 2 000 IU/mL)
d significant at P value < 0.001.