Figure 3.

Neuron-specific IRF4 overexpression is cerebroprotective during stroke. (a and b) The mice were subjected to I/R for 24 or 72 h. (a) TTC-stained brains from NTG and IRF4-TG mice at the indicated times after I/R. Scale bar: 10 mm. (b) Quantification of infarct volumes 24 and 72 h after I/R. Five to seven independent experiments were performed for each time point. (c) The mice were assessed for neurological deficit scores at the indicated time points. Five to seven independent experiments were performed for each time point. (d) Representative MRI images of live mice 24 h after I/R. Scale bar: 5mm. (e) Quantification of infarct volumes using MRI. Three to five independent experiments were performed. *P=0.0066 (b, 24 h), 0.0007 (b, 72 h), 0.0103 (c, 24 h), 0.0081 (c, 72 h) and 0.0086 (e) compared with NTG mice unpaired Student's t-test. The values are the means±S.E