Table 2. Total and individual scores of gastrointestinal symptoms in the 24 and 48 h following consumption of dairy desserts containing 35 g dextrose (control dessert) or different mixtures of maltitol and scFOS in the ITT population (n=36).
Control | Dextrose 24 scFOS 11 | Maltitol 35 | Maltitol 30 scFOS 5 | Maltitol 24 scFOS 11 | Maltitol 17.5 scFOS 17.5 | Dessert effect (P-value) | ||
---|---|---|---|---|---|---|---|---|
0–24 h | Total score | 3.15±4.26a | 6.46±5.85b | 8.86±6.49b,c | 8.53±7.10b,c | 9.41±6.99b,c | 10.80±7.98b,c | <0.0001 |
Flatulence | 1.21±1.49 | 2.11±2.26 | 3.37±2.56* | 2.74±2.50* | 3.68±2.46* | 4.11±2.34* | <0.0001 | |
Borborygmi | 0.70±1.31 | 1.49±2.01 | 2.11±2.40* | 2.41±2.43* | 1.85±2.30* | 2.43±2.40* | <0.0001 | |
Bloating | 0.70±1.69 | 1.40±2.20 | 1.60±2.24 | 1.74±2.15 | 1.82±2.41 | 2.17±2.72* | 0.0312 | |
Discomfort | 0.55±1.68 | 1.46±2.41 | 1.77±2.44* | 1.65±2.98 | 2.06±2.95* | 2.09±2.70* | 0.0135 | |
24–48 h | Total score | 0.88±1.71a | 2.34±3.55a,b | 3.60±5.39b | 2.62±3.57b | 2.24±3.37a,b | 2.71±4.26b | 0.0063 |
Flatulence | 0.27±0.80 | 0.83±1.50 | 1.37±1.99* | 1.12±1.61* | 1.06±1.54* | 1.20±1.78* | 0.0037 | |
Borborygmi | 0.30±0.81 | 0.31±0.93 | 0.74±1.60 | 0.79±1.49 | 0.44±1.13 | 0.57±1.29 | 0.0823 | |
Bloating | 0.12±0.55 | 0.49±1.17 | 0.69±1.64 | 0.35±0.92 | 0.47±1.02 | 0.57±1.36 | 0.2084 | |
Discomfort | 0.18±0.58 | 0.71±1.54 | 0.80±1.64* | 0.35±1.01 | 0.26±0.79 | 0.37±1.19 | 0.0448 |
Abbreviations: ITT, intention to treat; scFOS, short-chain fructo-oligosaccharides.
Each symptom is scored between 1 and 10; data is expressed in arbitrary unit mean±s.d.
Desserts not sharing the same letter are significantly different (P<0.05, Dunnett's post hoc test vs the Control or Tukey's test among the five other mixtures).
Significant increase (Dunnett's test) in gastrointestinal symptom scores compared with 35 g dextrose, P<0.05. Other observed differences (Tukey's test) for flatulence at 24 h: maltitol 24–scFOS 11 vs scFOS 11 (P=0.0197); maltitol 17.5–scFOS 17.5 vs scFOS 11 (P=0.0005); maltitol 17.5–scFOS 17.5 vs maltitol 30–scFOS 5 (P=0.0377).