Table 1.

Clinical features and vascular endothelial growth factor (VEGF)-A, VEGF receptors expression and microvessel density (MVD) in pheochromocytoma (PHEO) patients (n = 29).

Case	Phenotype	RET germline mutation	Age (years) 1/sex	Tumor size 2	VEGF-A 3	VEGFR-1 3	VEGFR-2 3	MVD 4
1	MEN 2 A	C618R	38/F	7.50	118.6	102.8	16	78.6
2	MEN 2 A	C634W	36/F	4.0	23.6	54	6.5	100
3	MEN 2 A	C634R	37/F	6.40	319	27.6	4.2	35.7
4	MEN 2 A	C634R	21/F	1.70	63.2	38.3	19.2	14.3
5	MEN 2 A	C634R	34/F	5.50	78.5	182	29.6	92.9
6	MEN 2 B	M918T	49/F	N/A	95.9	75.9	N/A	85.7
7	MEN 2 B	M918T	33/F	2.5	67.3	47.6	67.6	50
8	MEN 2 A	C634Y	61/M	N/A	199.1	35.5	38.7	50
9	MEN 2 A	C634Y	44/F	1.00	97.2	81.1	17.3	7.14
10	MEN 2 A	C634Y	49/M	1.20	222.9	101.6	75.9	7.14
11	MEN 2 A	C634Y	55/M	N/A	102.6	163	52.2	57.1
12	MEN 2 A	C634Y	62/F	3.50	220.1	35.8	4.5	42.9
13	MEN 2 A	C634Y	45/M	2.5	65.8	62.7	10.3	92.8
14	MEN 2 A	C634Y	23/M	1.4	112.5	253.1	33.2	50
15	Sporadic 5		14/F	6.50	143.5	64.6	338.1	92.8
16	Sporadic 5		30/F	8.20	284.8	116.7	180.8	92.9
17	Sporadic 5		23/M	13.0	194.1	195.2	91.3	85.7
18	Sporadic 5		52/M	4.0	147.9	78.6	125.5	85.7
19	Sporadic		20/F	5.50	130.1	37.3	45.1	64.3
20	Sporadic		18/M	6.00	76	50	1.6	50
21	Sporadic		34/F	11.5	89.4	87.9	16	50
22	Sporadic		45/F	4.00	135.7	229.7	81.4	42.9
23	Sporadic		39/F	5.50	51.4	68.5	13.4	85.7
24	Sporadic		23/F	3.50	33.4	71.9	0	92.8
25	Sporadic		23/F	8.50	77.4	92.5	135	42.9
26	Sporadic		35/F	11.0	160.6	157.7	28.1	35.7
27	Sporadic		38/F	7.50	101.8	16.6	2.3	57.1
28	Sporadic		61/F	3.5	44	101.2	45.3	64.3
29	Sporadic		58/M	3.4	81.4	28.5	9.9	57.1

N/A, no available;

¹age at diagnosis of PHEO;

²Greatest tumor diameter (cm);

³Pixels;

⁴MVD/mm²; and

⁵MalignantPHEO.