Table 2.
Associations between candidate SNPs in 15q25.1 and risk of lung ADC in a Chinese population.
| Codominant Model | Fitting Model | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Gene | SNP | Position | Allelesa | MAFb | Heterozygote OR (95% CI)c | Homozygote OR (95% CI)c | OR (95% CI)c | p Value |
| AGPHD1 | rs8034191 | 78806023 | T/C | 0.03/0.04 | 1.31 (0.63–2.73) | No polymorphism | ||
| CHRNA5 | rs16969968 | 78882925 | G/A | 0.04/0.04 | 1.14 (0.57–2.27) | No polymorphism | ||
| CHRNA3 | rs1051730 | 78894339 | C/T | 0.04/0.04 | 1.17 (0.58–2.35) | No polymorphism | ||
| rs938682 | 78896547 | T/C | 0.46/0.43 | 0.67 (0.43–1.03) | 0.71 (0.42–1.21) | 0.68 (0.45–1.02) | 0.063d | |
| rs8042374 | 78908032 | G/A | 0.27/0.28 | 1.76 (1.17–2.65) | 1.28 (0.59–2.75) | 1.71 (1.15–2.54) | 0.008e | |
a
Reference allele/risk allele;
b
Control/case;
c
Adjusted for age and gender;
d
Dominant model for rs938682;
e
Overdominant model for rs8042374. Bold mean p < 0.05.