Table 2.

Bioactivity of OHD and OHG.

Classification	Compound	Bioactivity	Ref.
Anticancer-Related Activity	3′-OHG	Antiproliferative activity toward T47D tumorigenic breast epithelial cells;	[52,53]
	8-OHD	Increases life span against S180 bearing mice;	[43]
		Suppression of MDR in Caco-2 colon adenocarcinoma cells;	[58]
	8-OHG	Antimutagenesis activity;	[36]
		Antiproliferative activity toward HL-60 promyelocytic leukemia cells;	[35]
	6-OHD	Suppression of HCT-116 colon cancer cell proliferation in vitro and in vivo;	[54]
	3′-OHD	Suppression of EGF receptor-positive skin cancer cell proliferation in vitro and in vivo;	[55,56]
		Suppression of MDR transporters;	[57]
Antimelanogenesis- Related Activity	6-OHD	Competitive tyrosinase inhibitor;	[60]
	8-OHD	Irreversible tyrosinase inhibitor;	[61,62]
		Antimelanogenesis activity in human volunteers;	[63]
	8-OHG	Irreversible tyrosinase inhibitor;	[61,62]
	3′-OHD	Antimelanogenesis activity in human skin equivalents;	[64,65]
		Potent autophage inducer;	[67]
Other Bioactivities	3′-OHG	HIV-1 integrase inhibitor;	[25]
		Antiinflammatory activity;	[68]
		Hepatoprotective activity;	[24]
	6-OHG	Hepatoprotective activity;	[46]
	8-OHD	Aldose reductase inhibitor;	[69]
	6-OHD	Suppression on adipogenesis of 3T3-L1 preadipocytes;	[70]
		Promoting differentiation of 3T3-L1 preadipocytes;	[71]
		Antitrypanosomal activity	[72]
	3′-OHD	Antitrypanosomal activity;	[72,73]
		Improving atopic dermatitis symptoms;	[74]