Table 3.

Production of OHD and OHG by recombinant microorganisms harboring heterogeneous monooxygenase. Products that are underlined have the highest reported values.

Monooxygenase name	Monooxygenase sources	Recombinant hosts	Products	Yield (mg/L)	Ref.
CYP107H1 a	B. subtilis	E. coli	3′-OHD	<0.1	[75]
Nfa33880 a	N. farcinica	E. coli	8-OHD 6-OHD	0.76 0.56	[76]
CYP154 a	N. farcinica	E. coli	3′-OHD	0.99	[77]
CYP102D1 b	S. avermitilis	E. coli	8-OHD 6-OHD	2.42 1.18	[78]
CYP105D7 c	S. avermitilis	S. avermitilis	3′-OHD	9.3	[79]
CYP105D7 a	S. avermitilis	S. avermitilis	3′-OHD	37.5	[80]
CYP107Y1 a	S. avermitilis	S. avermitilis	3′-OHG	6.75	[21]
Sam5	S. espanaensis	E. coli	3′-OHD	75	[82]
CYP57B3 a	A. oryzae	S. cerevisiae	3′-OHG	N.D. d	[16]
CYP57B3 c	A. oryzae	P. pastoris	6-OHD	9.1	[87]

^aCo-expressed with P450 reductase (camA/camB);

^bMutated CYP;

^cEngineered fusion with P450 reductase;

^dNot determined.