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. 2014 Apr 8;15(4):5884–5906. doi: 10.3390/ijms15045884

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 5. — The effect of binge intraperitoneal (i.p.) METH on the immunoreactivity of pre-synaptic dopamine D2 autoreceptor (D2S) in striatal synaptosomal fractions. Binge METH (4 × 10 mg/kg, every 2 h, i.p.) increased D2 receptor immunoreactivity at 1 h in total synaptosomal fraction (+32%, * p < 0.05) and decreased D2 receptor immunoreactivity at 24 h in all three fractions, total, membrane-endosomal, and cytosol-vesicular fraction (−34% (** p < 0.01), −28%, and −11%, respectively). A trend for an increase in D2S immunoreactivity was observed in cytosol-vesicular fraction (+48%, p = 0.069). Abbreviations: M, membrane fraction; METH, methamphetamine; PonS, Ponceau S; SAL, saline; T, total fraction; V, vesicular fraction.