Table 1.

Association of serum miR-196a and miR-196b levels with clinicopathological features of osteosarcoma.

Clinicopathological Features	No. of Cases	miR-196a-High (n, %)	p	miR-196b-High (n, %)	p	miR-196a-High/miR-196b-High (n, %)	p
Age
<18	32 (32.00)	20 (62.51)	NS	14 (43.75)	NS	12 (37.50)	NS
≥18	68 (68.00)	37 (54.41)		38 (55.88)		28 (41.18)
Sex
Male	70 (70.00)	40 (57.14)	NS	36 (51.73)	NS	28 (40.00)	NS
Female	30 (30.00)	17 (56.67)		16 (53.33)		12 (40.00)
Tumor Site
Femur	58 (58.00)	35 (60.34)	NS	30 (51.72)	NS	22 (37.93)	NS
Tibia	20 (20.00)	10 (50.00)		11 (55.00)		9 (45.00)
Humeral bone	15 (15.00)	8 (53.33)		8 (53.33)		6 (40.00)
Other	7 (7.00)	4 (57.14)		3 (42.86)		3 (42.86)
Histologic Type
Osteoblastic	52 (52.00)	30 (57.69)	NS	28 (53.85)	NS	20 (38.46)	NS
Chondroblastic	18 (18.00)	10 (55.56)		9 (50.00)		8 (44.44)
Fibroblastic	20 (20.00)	11 (55.00)		10 (50.00)		8 (40.00)
Telangiectatic	10 (10.00)	6 (60.00)		5 (50.00)		4 (40.00)
Tumor Grade
Low	38 (38.00)	15 (39.47)	0.008	12 (31.58)	0.01	8 (23.53)	<0.001
High	62 (62.00)	42 (67.74)		40 (64.52)		32 (51.61)
Metastasis
Absent	60 (60.00)	30 (50.00)	0.001	26 (43.33)	0.006	12 (20.00)	<0.001
Present	40 (40.00)	27 (67.50)		26 (65.00)		28 (70.00)
Recurrence
Absent	65 (65.00)	27 (41.54)	0.001	26 (40.00)	0.006	14 (21.54)	<0.001
Present	35 (35.00)	30 (85.71)		26 (74.29)		26 (74.29)
Response to Pre-Operative Chemotherapy
Good	60 (60.00)	31 (51.67)	NS	32 (53.33)	NS	22 (36.67)	NS
Poor	40 (40.00)	26 (65.00)		20 (50.00)		18 (45.00)