Table 2.
Multivariate survival analysis of overall survival (OS) and disease-free survival (DFS) in 100 patients with osteosarcoma.
| Variables | OS | DFS | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| RR | 95% CI | p | RR | 95% CI | p | |
| Tumor grade | 6.86 | 1.69–15.02 | 0.01 | 7.37 | 1.72–16.31 | 0.008 |
| Response to pre-operative chemotherapy | 3.58 | 0.80–7.21 | 0.04 | 4.02 | 1.01–8.38 | 0.03 |
| Metastasis status | 3.19 | 0.76–6.82 | NS | 3.56 | 0.80–7.19 | 0.04 |
| Recurrence status | 3.48 | 0.79–7.03 | NS | 4.00 | 1.00–8.06 | 0.03 |
| Serum miR-196a level | 6.28 | 1.62–13.39 | 0.01 | 6.95 | 1.63–14.61 | 0.01 |
| Serum miR-196b level | 6.33 | 1.61–13.48 | 0.01 | 6.98 | 1.65–14.82 | 0.01 |
| miR-196a/miR-196b expression | 9.89 | 2.66–20.98 | 0.001 | 10.09 | 2.82–21.99 | 0.001 |