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Genes with frequent inactivating mutations in intrahepatic cholangiocarcinoma. Inactivating mutations occurred throughout the coding sequences of BAP1, ARID1A and PBRM1. Rectangles, splice-site mutations; triangles, insertions and deletions; ovals, missense mutations; stars, nonsense mutations. H, HBM-like motif; BR, BRCA1-interacting domain; C, coiled-coil domain; N, nuclear localization signal; LXXLL, LXXLL domain; ARID, ARID domain; BD, bromodomain; BAH, BAH domain; HMG, HMG box.
