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. 2014 Feb 5;34(5):785–793. doi: 10.1038/jcbfm.2014.19

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Copyright © 2014 International Society for Cerebral Blood Flow & Metabolism, Inc.

This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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Comparison of T₂, magnetization transfer ratio (MTR), and apparent diffusion coefficient (ADC) sequences in SOD1^G93A and control mice at 120 days. Representative images from T₂ (i), MTR (ii), and ADC (iii) sequences (A) showed visible changes in SOD1^G93A mice for all nuclei (arrows) except for nucleus XII for ADC. Quantification of intensity changes in T₂, MTR, and ADC sequences in SOD1^G93A and control mice (B) indicate that a significant intensity change occurred for all three nuclei in all sequences. Note that intensity change for ADC and MTR has been inverted for comparison with T₂. *P<0.05; **P<0.01; ***P<0.001. N=5 in each group. Scale bar represents 1 mm, and applies to all images. SOD1, superoxide dismutase; ROI, region of interest.