Table 1. Summary of select parameters for mouse and rat cerebral hypoxia–ischemia.
| Mouse | Rat | |
|---|---|---|
| T2 (ms) | ||
| 3 hours | ||
| Lesion | 76±1 | 73±0.5 |
| Contralateral | 62±2 | 66±1 |
| 24 hours | ||
| Lesion | 78±8 | 81±2 |
| Contralateral | 58±6 | 64±1 |
| Trace (10−4 mm2/s) | ||
| 3 hours | ||
| Lesion | 5.3±0.4 | |
| Contralateral | 6.4±0.1 | |
| 24 hours | ||
| Lesion | 5.5±0.3 | |
| Contralateral | 6.5±0.2 | |
| [18F]FACE uptake, 30 minutes post injection (%ID/g) | ||
| 3 hours | ||
| Lesion | 10±0.8 | 1.9±0.3 |
| Contralateral | 7.0±0.6 | 1.0±0.1 |
| 24 hours | ||
| Lesion | 10±2 | 2.1±0.5 |
| Contralateral | 6.2±1 | 1.3±0.2 |
| Lesion volume (cc) | ||
| MRI (T2) | ||
| 3 hours | 0.0029±0.0005 | 0.30±0.05 |
| 24 hours | 0.048±0.1 | 0.16±0.09 |
| TTC | ||
| 3 hours | 0.019±0.01 | 0.075±0.03 |
| 24 hours | 0.15±0.1 | 0.16±0.09 |
| Neurological deficit score | ||
| 3 hours | 1.5, 2, 2 | 2.5, 3, 3.5, 4 |
| 24 hours | 0, 0, 2, 3 | 0, 1, 1.5, 2.5, 3 |
[18F]FACE, 2-[18F]fluoroacetate; MRI, magnetic resonance imaging; TTC, triphenyltetrazolium chloride.