Table 4. Mean microdialysate MDC concentrations (pg/mL)±standard error of mean.

Time in relation to drug administration	Day 1	Day 2	Day 3	Day 4	Day 5
Control group	38.1±11.2	39.0±11.8	40.3±103.4	44.2±16.0	45.4±17.5
Intervention group	8.4±1.7	9.4±2.0	9.6±2.0	9.6±1.8	1.04±1.9

IL1ra, interleukin-1 receptor antagonist; ANOVA, analysis of variance; MDC, macrophage-derived chemoattractant.

Mixed Model ANOVA: Test of between-subjects contrast (control group versus intervention group): F(1,18)=4.45, P=0.05. Test of within-subjects contrast (effect of time on IL1ra concentration): F(1,18)=0.38, P=0.383). Test of within-subject contrast (interaction between time and intervention/control group): F(1,18)=0.580, P=0.471.