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. 2014 Feb 12;34(5):852–860. doi: 10.1038/jcbfm.2014.24

Figure 1.

Figure 1

Body weight and mean arterial pressure (MAP) are reduced in dehydrated mice in a time-dependent manner (A, B). Dehydration leads to an increase in hematocrit and plasma osmolality proportional to the duration of dehydration (C, D). In addition, dehydration increases vasopressin (AVP) plasma levels and the number of AVP and c-Fos immunoreactive neurons in hypothalamic paraventricular nucleus of mice (E–G). The increase is not affected by the V1a receptor (V1aR) antagonist SR49059 (H, I). *P<0.05 versus vehicle (0 hour); #P<0.05 versus 24 hours dehydration; &P<0.05 versus c-Fos+/AVP+ (0 hour). Analysis of variance and Tukey's test; n=5 to 10/group. Calibration bar: 50 μm.