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Dehydration increases endothelin-1 (ET-1) levels in cerebral blood vessels, and effect blocked by SR49059 (A). Neocortical application of BQ123 (1 μmol/L) ameliorates the cerebrovascular dysfunction induced by dehydration (B–D). *P<0.05 versus vehicle (0 hour); analysis of variance and Tukey's test; n=8 to 10/group.
